Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3

We analyzed the immunoglobulin (Ig) variable heavy (IGHV) and variable light chain genes used by leukemia cells of 258 unrelated patients with chronic lymphocytic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-69 among 1846 CLL patients examined. We...

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Bibliographic Details
Main Authors: Widhopf, George F., Goldberg, Craig J., Toy, Traci L., Rassenti, Laura Z., Wierda, William G., Byrd, John C., Keating, Michael J., Gribben, John G., Rai, Kanti R., Kipps, Thomas J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265453/
https://ncbi.nlm.nih.gov/pubmed/17675554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-073130
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