Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3

We analyzed the immunoglobulin (Ig) variable heavy (IGHV) and variable light chain genes used by leukemia cells of 258 unrelated patients with chronic lymphocytic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-69 among 1846 CLL patients examined. We...

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Main Authors: Widhopf, George F., Goldberg, Craig J., Toy, Traci L., Rassenti, Laura Z., Wierda, William G., Byrd, John C., Keating, Michael J., Gribben, John G., Rai, Kanti R., Kipps, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265453/
https://ncbi.nlm.nih.gov/pubmed/17675554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-073130
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