Use of IGHV3–21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post–germinal center leukemogenic selection

We examined the chronic lymphocytic leukemia (CLL) cells of 2457 patients evaluated by the CLL Research Consortium (CRC) and found that 63 (2.6%) expressed immunoglobulin (Ig) encoded by the Ig heavy-chain-variable-region gene (IGHV), IGHV3-21. We identified the amino acid sequence DANGMDV (motif-1)...

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Autori principali: Ghia, Emanuela M., Jain, Sonia, Widhopf, George F., Rassenti, Laura Z., Keating, Michael J., Wierda, William G., Gribben, John G., Brown, Jennifer R., Rai, Kanti R., Byrd, John C., Kay, Neil E., Greaves, Andrew W., Kipps, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384137/
https://ncbi.nlm.nih.gov/pubmed/18326815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-130229
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