High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

ROR1 is an oncoembryonic orphan receptor found on chronic lymphocytic leukemia (CLL) B cells, but not on normal postpartum tissues. ROR1 is a receptor for Wnt5a that may complex with TCL1, a coactivator of AKT that is able to promote development of CLL. We found the CLL cells of a few patients expre...

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Publicado en:Blood
Main Authors: Cui, Bing, Ghia, Emanuela M., Chen, Liguang, Rassenti, Laura Z., DeBoever, Christopher, Widhopf, George F., Yu, Jian, Neuberg, Donna S., Wierda, William G., Rai, Kanti R., Kay, Neil E., Brown, Jennifer R., Jones, Jeffrey A., Gribben, John G., Frazer, Kelly A., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179332/
https://ncbi.nlm.nih.gov/pubmed/27815263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-712562
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