Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Coculture of nurse-like cells (NLCs) with chronic lymphocytic leukemia (CLL) cells induced leukemia cell phosphorylation of STAT3 (pSTAT3), which could be blocked by anti-Wnt5a antibodies or the anti-ROR1 monoclonal antibody, cirmtuzumab. Time-course studies revealed Wnt5a could induce activation of...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chen, Yun, Chen, Liguang, Yu, Jian, Ghia, Emanuela M., Choi, Michael Y., Zhang, Ling, Zhang, Suping, Sanchez-Lopez, Elsa, Widhopf, George F., Messer, Karen, Rassenti, Laura Z., Jamieson, Catriona, Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764264/
https://ncbi.nlm.nih.gov/pubmed/31409670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001366
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