Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. We found that Wnt5a enhanced proliferation and migration of chronic lymphocyti...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yu, Jian, Chen, Liguang, Cui, Bing, Widhopf, George F., Shen, Zhouxin, Wu, Rongrong, Zhang, Ling, Zhang, Suping, Briggs, Steven P., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731190/
https://ncbi.nlm.nih.gov/pubmed/26690702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83535
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