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Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis
ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1. Wnt5a also induced ROR1-dependent tyrosine phosphorylation of cortactin (Y421), which recruited ARHG...
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| Publicado no: | NPJ Breast Cancer |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6814774/ https://ncbi.nlm.nih.gov/pubmed/31667337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-019-0131-9 |
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