Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic protein expressed on chronic lymphocytic leukemia (CLL) that can serve as a receptor for Wnt5a, which can promote leukemia cell migration, proliferation, and survival. We found Wnt5a could induce ROR1 to complex with DOCK2 (d...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Hasan, Md Kamrul, Yu, Jian, Widhopf, George F., Rassenti, Laura Z., Chen, Liguang, Shen, Zhouxin, Briggs, Steven P., Neuberg, Donna S., Kipps, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043980/
https://ncbi.nlm.nih.gov/pubmed/29678828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-819383
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