Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to compl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Leukemia
Egile Nagusiak: Yu, J, Chen, L, Chen, Y, Hasan, M K, Ghia, E M, Zhang, L, Wu, R, Rassenti, L Z, Widhopf, G F, Shen, Z, Briggs, S P, Kipps, T J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670032/
https://ncbi.nlm.nih.gov/pubmed/28465528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.132
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