Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune precipitates of Wnt5a-activated ROR1 identified 14-3-3ζ, which was confirmed by co-immunoprecipitation. The capacity of Wnt5a to induce ROR1 to compl...

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Bibliografische gegevens
Gepubliceerd in:Leukemia
Hoofdauteurs: Yu, J, Chen, L, Chen, Y, Hasan, M K, Ghia, E M, Zhang, L, Wu, R, Rassenti, L Z, Widhopf, G F, Shen, Z, Briggs, S P, Kipps, T J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670032/
https://ncbi.nlm.nih.gov/pubmed/28465528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.132
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