Computational Identification Of CDR3 Sequence Archetypes Among Immunoglobulin Sequences in Chronic Lymphocytic Leukemia

The leukemia cells of unrelated patients with chronic lymphocytic leukemia (CLL) display a restricted repertoire of immunoglobulin (Ig) gene rearrangements with preferential usage of certain Ig gene segments. We developed a computational method to rigorously quantify biases in Ig sequence similarity...

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Bibliographic Details
Main Authors: Messmer, Bradley T, Raphael, Benjamin J, Aerni, Sarah J, Widhopf, George F, Rassenti, Laura Z, Gribben, John G, Kay, Neil E, Kipps, Thomas J
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692898/
https://ncbi.nlm.nih.gov/pubmed/18640719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.05.022
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