Quantitative DNA Methylation Analysis Identifies a Single CpG Dinucleotide Important for ZAP-70 Expression and Predictive of Prognosis in Chronic Lymphocytic Leukemia

PURPOSE: Increased ZAP-70 expression predicts poor prognosis in chronic lymphocytic leukemia (CLL). Current methods for accurately measuring ZAP-70 expression are problematic, preventing widespread application of these tests in clinical decision making. We therefore used comprehensive DNA methylatio...

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Bibliographic Details
Main Authors: Claus, Rainer, Lucas, David M., Stilgenbauer, Stephan, Ruppert, Amy S., Yu, Lianbo, Zucknick, Manuela, Mertens, Daniel, Bühler, Andreas, Oakes, Christopher C., Larson, Richard A., Kay, Neil E., Jelinek, Diane F., Kipps, Thomas J., Rassenti, Laura Z., Gribben, John G., Döhner, Hartmut, Heerema, Nyla A., Marcucci, Guido, Plass, Christoph, Byrd, John C.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2012
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397783/
https://ncbi.nlm.nih.gov/pubmed/22564988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.39.3090
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