KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Ficarelli, Mattia, Wilson, Harry, Pedro Galão, Rui, Mazzon, Michela, Antzin-Anduetza, Irati, Marsh, Mark, Neil, Stuart JD, Swanson, Chad M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2019
Konular:
Immunology and Inflammation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615859/
https://ncbi.nlm.nih.gov/pubmed/31284899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46767
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