KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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Pubblicato in:eLife
Autori principali: Ficarelli, Mattia, Wilson, Harry, Pedro Galão, Rui, Mazzon, Michela, Antzin-Anduetza, Irati, Marsh, Mark, Neil, Stuart JD, Swanson, Chad M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615859/
https://ncbi.nlm.nih.gov/pubmed/31284899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46767
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