KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ficarelli, Mattia, Wilson, Harry, Pedro Galão, Rui, Mazzon, Michela, Antzin-Anduetza, Irati, Marsh, Mark, Neil, Stuart JD, Swanson, Chad M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615859/
https://ncbi.nlm.nih.gov/pubmed/31284899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46767
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