Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

The mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC) is negatively regulated by reversible phosphorylation. BCKDC kinase (BDK) inhibitors that augment BCKDC flux have been shown to reduce branched-chain amino acid (BCAA) concentrations in vivo. In the present study, we employed...

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Autori principali: Tso, Shih-Chia, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Qi, Xiangbing, Skvorak, Kristen J., Dorko, Kenneth, Wallace, Amy L., Morlock, Lorraine K., Lee, Brendan H., Hutson, Susan M., Strom, Stephen C., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110271/
https://ncbi.nlm.nih.gov/pubmed/24895126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569251
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