Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Pyruvate dehydrogenase kinase isoforms (PDKs 1–4) negatively regulate activity of the mitochondrial pyruvate dehydrogenase complex by reversible phosphorylation. PDK isoforms are up-regulated in obesity, diabetes, heart failure, and cancer and are potential therapeutic targets for these important hu...

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Главные авторы: Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Wernstedt-Asterholm, Ingrid, Morlock, Lorraine K., Owens, Kyle R., Scherer, Philipp E., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924305/
https://ncbi.nlm.nih.gov/pubmed/24356970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533885
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