Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

OBJECTIVE: Mitochondrial pyruvate dehydrogenase kinases 1–4 (PDKs1–4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal role in maintaining energy homeostasis and contribute to metabolic flexibility by attenuating PDC activity...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Wu, Cheng-Yang, Tso, Shih-Chia, Chuang, Jacinta L., Gui, Wen-Jun, Lou, Mingliang, Sharma, Gaurav, Khemtong, Chalermchai, Qi, Xiangbing, Wynn, R. Max, Chuang, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001905/
https://ncbi.nlm.nih.gov/pubmed/29656110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.03.014
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