The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions

The carbohydrate response element binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. In response to fluctuating blood glucose levels ChREBP activity is regulated mainl...

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Veröffentlicht in:Biochem J
Hauptverfasser: Jung, Hunmin, Takeshima, Tomomi, Nakagawa, Tsutomu, MacMillan, Karen S., Wynn, R. Max, Wang, Hanzhi, Sakiyama, Haruhiko, Wei, Shuguang, Li, Yang, Bruick, Richard K., Posner, Bruce A., De Brabander, Jef K., Uyeda, Kosaku
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2020
Schlagworte:
Biochemical Techniques & Resources
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489895/
https://ncbi.nlm.nih.gov/pubmed/32776146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200520
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