A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain α-ketoacid dehydrogenase complex

The dihydrolipoamide acyltransferase (E2b) component of the branched-chain α-ketoacid dehydrogenase complex forms a cubic scaffold that catalyzes acyltransfer from S-acyldihydrolipoamide to CoA to produce acyl-CoA. We have determined the first crystal structures of a mammalian (bovine) E2b core doma...

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Bibliografiset tiedot
Päätekijät: Kato, Masato, Wynn, R Max, Chuang, Jacinta L, Brautigam, Chad A, Custorio, Myra, Chuang, David T
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698891/
https://ncbi.nlm.nih.gov/pubmed/17124494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601444
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