Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex

The purified mammalian branched-chain α-ketoacid dehydrogenase complex (BCKDC), which catalyzes the oxidative decarboxylation of branched-chain α-keto acids, is essentially devoid of the constituent dihydrolipoamide dehydrogenase component (E3). The absence of E3 is associated with the low affinity...

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Detalhes bibliográficos
Main Authors: Brautigam, Chad A., Wynn, R. Max, Chuang, Jacinta L., Naik, Mandar T., Young, Brittany B., Huang, Tai-huang, Chuang, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123111/
https://ncbi.nlm.nih.gov/pubmed/21543315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202960
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