A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and Human Receptors

[Image: see text] Recent progress in the discovery of mGlu(1) allosteric modulators has suggested the modulation of mGlu(1) could offer possible treatment for a number of central nervous system disorders; however, the available chemotypes are inadequate to fully investigate the therapeutic potential...

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Detalhes bibliográficos
Main Authors: Cho, Hyekyung P., Engers, Darren W., Venable, Daryl F., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey, Emmitte, Kyle A., Rodriguez, Alice L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102972/
https://ncbi.nlm.nih.gov/pubmed/24798819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn5000343
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