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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we describe dimeric RNA-guided FokI Nucleases (RFNs) that recognize extended sequences and can edit endogenous genes with high efficiencies in human ce...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4090141/ https://ncbi.nlm.nih.gov/pubmed/24770325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2908 |
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