APC(Cdc20) Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

APC(Cdc20) plays pivotal roles in governing mitotic progression. By suppressing APC(Cdc20), anti-mitotic agents activate the spindle-assembly-checkpoint (SAC), and induce apoptosis after prolonged-treatment, while depletion of endogenous Cdc20 suppresses in vivo tumorigenesis in part by triggering m...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Wan, Lixin, Tan, Mingjia, Yang, Jie, Inuzuka, Hiroyuki, Dai, Xiangpeng, Wu, Tao, Liu, Jia, Shaik, Shavali, Chen, Guoan, Deng, Jing, Malumbres, Marcos, Letai, Anthony, Kirschner, Marc W., Sun, Yi, Wei, Wenyi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2014
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081014/
https://ncbi.nlm.nih.gov/pubmed/24871945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.04.022
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