APC(Cdc20) Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

APC(Cdc20) plays pivotal roles in governing mitotic progression. By suppressing APC(Cdc20), anti-mitotic agents activate the spindle-assembly-checkpoint (SAC), and induce apoptosis after prolonged-treatment, while depletion of endogenous Cdc20 suppresses in vivo tumorigenesis in part by triggering m...

Full description

Saved in:
Bibliographic Details
Main Authors: Wan, Lixin, Tan, Mingjia, Yang, Jie, Inuzuka, Hiroyuki, Dai, Xiangpeng, Wu, Tao, Liu, Jia, Shaik, Shavali, Chen, Guoan, Deng, Jing, Malumbres, Marcos, Letai, Anthony, Kirschner, Marc W., Sun, Yi, Wei, Wenyi
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081014/
https://ncbi.nlm.nih.gov/pubmed/24871945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.04.022
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items