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Regulation of mTORC1 by amino acids

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases, including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutri...

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Hlavní autoři: Bar-Peled, Liron, Sabatini, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074565/
https://ncbi.nlm.nih.gov/pubmed/24698685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2014.03.003
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