ATRA-Induced Cellular Differentiation and CD38 Expression Inhibits Acquisition of BCR-ABL Mutations for CML Acquired Resistance

Acquired resistance through genetic mutations is a major obstacle in targeted cancer therapy, but the underlying mechanisms are poorly understood. Here we studied mechanisms of acquired resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) by examining genome-wide gene ex...

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Detalhes bibliográficos
Main Authors: Wang, Zhiqiang, Liu, Zheng, Wu, Xiwei, Chu, Su, Wang, Jinhui, Yuan, Hongfeng, Roth, Mendel, Yuan, Yate-Ching, Bhatia, Ravi, Chen, WenYong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072521/
https://ncbi.nlm.nih.gov/pubmed/24967705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004414
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