Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms for resistance of CML to tyrosine kinase inhibitors are not fully understood. In t...

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Bibliographische Detailangaben
Hauptverfasser: Yuan, Hongfeng, Wang, Zhiqiang, Li, Ling, Zhang, Hao, Modi, Hardik, Horne, David, Bhatia, Ravi, Chen, WenYong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293644/
https://ncbi.nlm.nih.gov/pubmed/22207735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361691
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