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Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms for resistance of CML to tyrosine kinase inhibitors are not fully understood. In t...

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Autors principals: Yuan, Hongfeng, Wang, Zhiqiang, Li, Ling, Zhang, Hao, Modi, Hardik, Horne, David, Bhatia, Ravi, Chen, WenYong
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293644/
https://ncbi.nlm.nih.gov/pubmed/22207735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361691
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