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Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms for resistance of CML to tyrosine kinase inhibitors are not fully understood. In t...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293644/ https://ncbi.nlm.nih.gov/pubmed/22207735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361691 |
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