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Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

The tyrosine kinase inhibitor imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired resistance of CML cells to the drug offset its efficacy. Molecular mechanisms for resistance of CML to tyrosine kinase inhibitors are not fully understood. In t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yuan, Hongfeng, Wang, Zhiqiang, Li, Ling, Zhang, Hao, Modi, Hardik, Horne, David, Bhatia, Ravi, Chen, WenYong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293644/
https://ncbi.nlm.nih.gov/pubmed/22207735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361691
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