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SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
BCR-ABL transforms bone marrow progenitor cells and promotes genome instability, leading to development of chronic myelogenous leukemia (CML). The tyrosine kinase inhibitor imatinib effectively treats CML, but acquired resistance can develop due to BCR-ABL mutations. Mechanisms for acquisition of BC...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376246/ https://ncbi.nlm.nih.gov/pubmed/22410779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.83 |
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