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SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells

Acquisition of BCR-ABL mutations underlies drug resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors, but the molecular mechanisms of mutation acquisition are poorly understood. We previously showed that lysine deacetylase sirtuin 1, SIRT1, promotes acquisition of BCR-ABL mutat...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Roth, Mendel, Wang, Zhiqiang, Chen, Wen Yong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226577/
https://ncbi.nlm.nih.gov/pubmed/27384990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10328
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