Mutant huntingtin impairs Ku70-mediated DNA repair

DNA repair defends against naturally occurring or disease-associated DNA damage during the long lifespan of neurons and is implicated in polyglutamine disease pathology. In this study, we report that mutant huntingtin (Htt) expression in neurons causes double-strand breaks (DSBs) of genomic DNA, and...

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Détails bibliographiques
Auteurs principaux: Enokido, Yasushi, Tamura, Takuya, Ito, Hikaru, Arumughan, Anup, Komuro, Akihiko, Shiwaku, Hiroki, Sone, Masaki, Foulle, Raphaele, Sawada, Hirohide, Ishiguro, Hiroshi, Ono, Tetsuya, Murata, Miho, Kanazawa, Ichiro, Tomilin, Nikolai, Tagawa, Kazuhiko, Wanker, Erich E., Okazawa, Hitoshi
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2010
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867301/
https://ncbi.nlm.nih.gov/pubmed/20439996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200905138
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