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Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair
Affinity maturation of antibodies requires a unique process of targeted mutation that allows changes to accumulate in the antibody genes while the rest of the genome is protected from off-target mutations that can be oncogenic. This targeting requires that the same deamination event be repaired eith...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4079052/ https://ncbi.nlm.nih.gov/pubmed/21256093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.12.005 |
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