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Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair

Affinity maturation of antibodies requires a unique process of targeted mutation that allows changes to accumulate in the antibody genes while the rest of the genome is protected from off-target mutations that can be oncogenic. This targeting requires that the same deamination event be repaired eith...

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Autors principals: Paddock, M.N., Bauman, A.T., Higdon, R., Kolker, E., Takeda, S., Scharenberg, A.M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079052/
https://ncbi.nlm.nih.gov/pubmed/21256093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.12.005
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