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The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion
Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect the genome from dangerous, potentially oncogenic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907289/ https://ncbi.nlm.nih.gov/pubmed/20652015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000428 |
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