HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death. We have shown that, in neuroblastoma cells, the bin...

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Autores principales: Subramanian, Chitra, Jarzembowski, Jason A, Opipari, Anthony W, Castle, Valerie P, Kwok, Roland PS
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156663/
https://ncbi.nlm.nih.gov/pubmed/21847364
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