CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in neuroblastic-type NB cells by increasing the acetylation of Ku70, a Bax-binding protein. Ku70 acetylation causes Bax release and activation,...

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Bibliographic Details
Main Authors:	Subramanian, Chitra, Jarzembowski, Jason A, Opipari, Anthony W, Castle, Valerie P, Kwok, Roland P S
Format:	Artigo
Language:	Inglês
Published:	Neoplasia Press Inc. 2007
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1899529/ https://ncbi.nlm.nih.gov/pubmed/17603632
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CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

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