CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in neuroblastic-type NB cells by increasing the acetylation of Ku70, a Bax-binding protein. Ku70 acetylation causes Bax release and activation,...

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Autores principales: Subramanian, Chitra, Jarzembowski, Jason A, Opipari, Anthony W, Castle, Valerie P, Kwok, Roland P S
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899529/
https://ncbi.nlm.nih.gov/pubmed/17603632
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