Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD patients and in mouse models of the disease. Fur...

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Hlavní autoři: Menalled, Liliana B., Kudwa, Andrea E., Oakeshott, Steve, Farrar, Andrew, Paterson, Neil, Filippov, Igor, Miller, Sam, Kwan, Mei, Olsen, Michael, Beltran, Jose, Torello, Justin, Fitzpatrick, Jon, Mushlin, Richard, Cox, Kimberly, McConnell, Kristi, Mazzella, Matthew, He, Dansha, Osborne, Georgina F., Al-Nackkash, Rand, Bates, Gill P., Tuunanen, Pasi, Lehtimaki, Kimmo, Brunner, Dani, Ghavami, Afshin, Ramboz, Sylvie, Park, Larry, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Howland, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067284/
https://ncbi.nlm.nih.gov/pubmed/24955833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099520
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