A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease

Apathy, characterized by generally reduced interest in and likelihood to perform goal-directed actions, is a recognized symptom of Huntington’s disease (HD), a devastating neurological disorder caused by a CAG repeat expansion of the Htt gene located on chromosome 4. The present experiments used a m...

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Main Authors: Oakeshott, Stephen, Port, Russell, Cummins-Sutphen, Jane, Berger, Jason, Watson-Johnson, Judy, Ramboz, Sylvie, Paterson, Neil, Kwak, Seung, Howland, David, Brunner, Dani
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
HD Models
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729251/
https://ncbi.nlm.nih.gov/pubmed/23925262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/4f972cffe82c0
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