Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits

The genome of the Bacterial Artificial Chromosome (BAC) transgenic mouse model of Huntington’s Disease (BAC HD) contains the 170 kb human HTT locus modified by the addition of exon 1 with 97 mixed CAA-CAG repeats. BAC HD mice present robust behavioral deficits in both the open field and the accelera...

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Bibliografiska uppgifter
Huvudupphovsmän: Kudwa, Andrea E., Menalled, Liliana B., Oakeshott, Stephen, Murphy, Carol, Mushlin, Richard, Fitzpatrick, John, Miller, Sam F., McConnell, Kristi, Port, Russell, Torello, Justin, Howland, David, Ramboz, Sylvie, Brunner, Dani
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
HD Models
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770835/
https://ncbi.nlm.nih.gov/pubmed/24042107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198
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