Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits

The genome of the Bacterial Artificial Chromosome (BAC) transgenic mouse model of Huntington’s Disease (BAC HD) contains the 170 kb human HTT locus modified by the addition of exon 1 with 97 mixed CAA-CAG repeats. BAC HD mice present robust behavioral deficits in both the open field and the accelera...

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Detalhes bibliográficos
Main Authors: Kudwa, Andrea E., Menalled, Liliana B., Oakeshott, Stephen, Murphy, Carol, Mushlin, Richard, Fitzpatrick, John, Miller, Sam F., McConnell, Kristi, Port, Russell, Torello, Justin, Howland, David, Ramboz, Sylvie, Brunner, Dani
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
HD Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770835/
https://ncbi.nlm.nih.gov/pubmed/24042107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198
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