Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits

The genome of the Bacterial Artificial Chromosome (BAC) transgenic mouse model of Huntington’s Disease (BAC HD) contains the 170 kb human HTT locus modified by the addition of exon 1 with 97 mixed CAA-CAG repeats. BAC HD mice present robust behavioral deficits in both the open field and the accelera...

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Main Authors: Kudwa, Andrea E., Menalled, Liliana B., Oakeshott, Stephen, Murphy, Carol, Mushlin, Richard, Fitzpatrick, John, Miller, Sam F., McConnell, Kristi, Port, Russell, Torello, Justin, Howland, David, Ramboz, Sylvie, Brunner, Dani
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
HD Models
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770835/
https://ncbi.nlm.nih.gov/pubmed/24042107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198
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