Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits

The genome of the Bacterial Artificial Chromosome (BAC) transgenic mouse model of Huntington’s Disease (BAC HD) contains the 170 kb human HTT locus modified by the addition of exon 1 with 97 mixed CAA-CAG repeats. BAC HD mice present robust behavioral deficits in both the open field and the accelera...

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Autors principals: Kudwa, Andrea E., Menalled, Liliana B., Oakeshott, Stephen, Murphy, Carol, Mushlin, Richard, Fitzpatrick, John, Miller, Sam F., McConnell, Kristi, Port, Russell, Torello, Justin, Howland, David, Ramboz, Sylvie, Brunner, Dani
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
HD Models
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770835/
https://ncbi.nlm.nih.gov/pubmed/24042107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198
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