Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been developed using different gene constructs of...

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Bibliografiset tiedot
Päätekijät: Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J., Glaser, Jack R., Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M., Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2012
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527436/
https://ncbi.nlm.nih.gov/pubmed/23284644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050717
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