Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

PURPOSE: Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatum, and D2R could be a reliable quantitative target to monito...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EJNMMI Radiopharm Chem
Main Authors: Huhtala, Tuulia, Poutiainen, Pekka, Rytkönen, Jussi, Lehtimäki, Kimmo, Parkkari, Teija, Kasanen, Iiris, Airaksinen, Anu J., Koivula, Teija, Sweeney, Patrick, Kontkanen, Outi, Wityak, John, Dominiquez, Celia, Park, Larry C.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682833/
https://ncbi.nlm.nih.gov/pubmed/31659519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41181-019-0071-6
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