Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD patients and in mouse models of the disease. Fur...

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Egile Nagusiak: Menalled, Liliana B., Kudwa, Andrea E., Oakeshott, Steve, Farrar, Andrew, Paterson, Neil, Filippov, Igor, Miller, Sam, Kwan, Mei, Olsen, Michael, Beltran, Jose, Torello, Justin, Fitzpatrick, Jon, Mushlin, Richard, Cox, Kimberly, McConnell, Kristi, Mazzella, Matthew, He, Dansha, Osborne, Georgina F., Al-Nackkash, Rand, Bates, Gill P., Tuunanen, Pasi, Lehtimaki, Kimmo, Brunner, Dani, Ghavami, Afshin, Ramboz, Sylvie, Park, Larry, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Howland, David
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067284/
https://ncbi.nlm.nih.gov/pubmed/24955833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099520
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