Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

We report a methodology that combines affinity acetylation with MS analysis for accurate mapping of an inhibitor-binding site to a target protein. For this purpose, we used a known HIV-1 integrase inhibitor containing aryl di-O-acetyl groups (Acetylated-Inhibitor). In addition, we designed a control...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Shkriabai, Nick, Patil, Sachindra S., Hess, Sonja, Budihas, Scott R., Craigie, Robert, Burke, Terrence R., Le Grice, Stuart F. J., Kvaratskhelia, Mamuka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC406438/
https://ncbi.nlm.nih.gov/pubmed/15118107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400873101
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller