Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

The importance of understanding the molecular mechanisms of murine leukemia virus (MLV) integration into host chromatin is highlighted by the development of MLV-based vectors for human gene-therapy. We have recently identified BET proteins (Brd2, 3 and 4) as the main cellular binding partners of MLV...

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Detalhes bibliográficos
Main Authors: Larue, Ross C., Plumb, Matthew R., Crowe, Brandon L., Shkriabai, Nikoloz, Sharma, Amit, DiFiore, Julia, Malani, Nirav, Aiyer, Sriram S., Roth, Monica J., Bushman, Frederic D., Foster, Mark P., Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005663/
https://ncbi.nlm.nih.gov/pubmed/24520112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku135
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