Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

The importance of understanding the molecular mechanisms of murine leukemia virus (MLV) integration into host chromatin is highlighted by the development of MLV-based vectors for human gene-therapy. We have recently identified BET proteins (Brd2, 3 and 4) as the main cellular binding partners of MLV...

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Autori principali: Larue, Ross C., Plumb, Matthew R., Crowe, Brandon L., Shkriabai, Nikoloz, Sharma, Amit, DiFiore, Julia, Malani, Nirav, Aiyer, Sriram S., Roth, Monica J., Bushman, Frederic D., Foster, Mark P., Kvaratskhelia, Mamuka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Gene Regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005663/
https://ncbi.nlm.nih.gov/pubmed/24520112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku135
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