Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Br...

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書誌詳細
主要な著者: Aiyer, Sriram, Swapna, G.V.T., Malani, Nirav, Aramini, James M., Schneider, William M., Plumb, Matthew R., Ghanem, Mustafa, Larue, Ross C., Sharma, Amit, Studamire, Barbara, Kvaratskhelia, Mamuka, Bushman, Frederic D., Montelione, Gaetano T., Roth, Monica J.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2014
主題:
Structural Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027182/
https://ncbi.nlm.nih.gov/pubmed/24623816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku175
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