Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Br...

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Detalhes bibliográficos
Main Authors: Aiyer, Sriram, Swapna, G.V.T., Malani, Nirav, Aramini, James M., Schneider, William M., Plumb, Matthew R., Ghanem, Mustafa, Larue, Ross C., Sharma, Amit, Studamire, Barbara, Kvaratskhelia, Mamuka, Bushman, Frederic D., Montelione, Gaetano T., Roth, Monica J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027182/
https://ncbi.nlm.nih.gov/pubmed/24623816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku175
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