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Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

The bromodomain and extraterminal domain (BET) protein family are promising therapeutic targets for a range of diseases linked to transcriptional activation, cancer, viral latency, and viral integration. Tandem bromodomains selectively tether BET proteins to chromatin by engaging cognate acetylated...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Crowe, Brandon L., Larue, Ross C., Yuan, Chunhua, Hess, Sonja, Kvaratskhelia, Mamuka, Foster, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776507/
https://ncbi.nlm.nih.gov/pubmed/26858406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516813113
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