Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin i...

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Hlavní autoři: Eidahl, Jocelyn O., Crowe, Brandon L., North, Justin A., McKee, Christopher J., Shkriabai, Nikoloz, Feng, Lei, Plumb, Matthew, Graham, Robert L., Gorelick, Robert J., Hess, Sonja, Poirier, Michael G., Foster, Mark P., Kvaratskhelia, Mamuka
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616739/
https://ncbi.nlm.nih.gov/pubmed/23396443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt074
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