Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin i...

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Detalhes bibliográficos
Main Authors: Eidahl, Jocelyn O., Crowe, Brandon L., North, Justin A., McKee, Christopher J., Shkriabai, Nikoloz, Feng, Lei, Plumb, Matthew, Graham, Robert L., Gorelick, Robert J., Hess, Sonja, Poirier, Michael G., Foster, Mark P., Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616739/
https://ncbi.nlm.nih.gov/pubmed/23396443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt074
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