Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin i...

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Bibliografiske detaljer
Main Authors: Eidahl, Jocelyn O., Crowe, Brandon L., North, Justin A., McKee, Christopher J., Shkriabai, Nikoloz, Feng, Lei, Plumb, Matthew, Graham, Robert L., Gorelick, Robert J., Hess, Sonja, Poirier, Michael G., Foster, Mark P., Kvaratskhelia, Mamuka
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616739/
https://ncbi.nlm.nih.gov/pubmed/23396443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt074
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