FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

A tetramer of HIV-1 integrase (IN) stably associates with the viral DNA ends to form a fully functional concerted integration intermediate. LEDGF/p75, a key cellular binding partner of the lentiviral enzyme, also stabilizes a tetrameric form of IN. However, functional assays have indicated the impor...

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Detalhes bibliográficos
Main Authors: Kessl, Jacques J., Li, Min, Ignatov, Michael, Shkriabai, Nikolozi, Eidahl, Jocelyn O., Feng, Lei, Musier-Forsyth, Karin, Craigie, Robert, Kvaratskhelia, Mamuka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203615/
https://ncbi.nlm.nih.gov/pubmed/21771857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr581
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